Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy-Reference-Cited by-同舟云学术

Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy

Published:2012-02-05 Issue:1 Volume:37 Page:17-22
ISSN:0378-7966
Container-title:European Journal of Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Eur J Drug Metab Pharmacokinet

Author:

Milner Erin,Sousa Jason,Pybus Brandon,Auschwitz Jennifer,Caridha Diana,Gardner Sean,Grauer Kristina,Harris Erin,Hickman Mark,Kozar Michael P.,Lee Patricia,Leed Susan,Li Qigui,Melendez Victor,Moon Jay,Ngundam Franklyn,O’Neil Michael,Parriott Sandi,Potter Brittney,Sciotti Rick,Tangteung Anchalee,Dow Geoffrey S.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/s13318-012-0080-2.pdf

Reference18 articles.

1. Begue JM, Le Bigot JF, Guguen-Guillouzo C, Kiechel JR, Guillouzo A (1983) Cultured human adult hepatocytes: a new model for drug metabolism studies. Biochem Pharmacol 32:1643–1646

2. Caridha D, Yourick D, Cabezas M, Wolf L, Hudson TH, Dow GS (2008) Mefloquine-induced disruption of calcium homeostasis in mammalian cells is similar to that induced by ionomycin. Antimicrob Agents Chemother 52:684–693

3. Derbyshire ER, Mota MM, Clardy J (2011) The next opportunity in anti-malaria drug discovery: the liver stage. PLoS Pathol 7(9):e1002178

4. Desjardins RE, Canfield CJ, Haynes JD, Chulay JD (1979) Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother 16:710–718

5. Huang WZ, Luo MZ, Zhou MX, Pan XQ (1987) Study of treatment of Plasmodium cynomolgi infection of macaques with ketotifen. Acta Pharm Sin 22(6):409–412

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action;Frontiers in Cellular and Infection Microbiology;2023-12-15

2. Ketotifen is a Prodrug. Norketotifen is the active metabolite.;Drug Development Research;2021-08-19

3. A computational approach for designing novel SARS-CoV-2 Mpro inhibitors: combined QSAR, molecular docking, and molecular dynamics simulation techniques;New Journal of Chemistry;2021

4. ANTIPLASMODIAL ACTIVITY OF KETOTIFEN-ARTEMETHER-LUMEFANTRINE ON PLASMODIUM BERGHEI INFECTED MICE;International Journal of Research -GRANTHAALAYAH;2020-12-11

5. Antiplasmodial Activity of Ketotifen-Artemether-Lumefantrine on Plasmodium Berghei Infected Mice;Health Sciences;2020-10-22