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Ketotifen is a Prodrug. Norketotifen is the active metabolite.

  • Published:2021-08-19 Issue: Volume: Page:
  • ISSN:0272-4391
  • Container-title:Drug Development Research
  • language:en
  • Short-container-title:Drug Dev Res

Author:

Aberg Axel Karl Gunnar1,Arulnesan Nada2,Bolger Gordon T.3ORCID,Ciofalo Vincent B.1,Pucaj Kresimir4,Walle Kristina5,Walle Thomas5

Affiliation:

1. Bridge Pharma, Inc. Sarasota Florida USA

2. Department of Toxicology Nucro‐Technics Scarborough Ontario Canada

3. GO‐TO‐PK Solutions Ajax Ontario Canada

4. Bridge Pharma Toronto, Inc. Scarborough Ontario Canada

5. Department of Pharmacology Medical University of South Carolina Charleston South Carolina USA

Publisher

Wiley

Subject

Drug Discovery

Reference14 articles.

1. Characterization and Validation of a Canine Pruritic Model

2. AbergAKG WrightGE ChenJL MaioliAT.2007.Optically active isomers of Ketotifen and therapeutically active metabolites thereof(US Patent 7 226 934).

3. Determination of ketotifen and its conjugated metabolite in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study

4. Ketotifen

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