Single- and Multiple-Dose Pharmacokinetics and Safety of Vilaprisan in Healthy Postmenopausal Japanese Women: A Randomized Clinical Trial
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology
Link
https://link.springer.com/content/pdf/10.1007/s13318-021-00727-8.pdf
Reference10 articles.
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2. Schultze-Mosgau M-H, Schuett B, Hafner F-T, Zollmann F, Kaiser A, Hoechel J, Rohde B. Pharmacokinetics and safety of the selective progesterone receptor modulator vilaprisan in healthy postmenopausal women. Int J Clin Pharmacol Ther. 2017;55:16–24. https://doi.org/10.5414/CP202756.
3. Schultze-Mosgau M-H, Höchel J, Prien O, Zimmermann T, Brooks A, Bush J, Rottmann A. Characterization of the pharmacokinetics of vilaprisan: bioavailability, excretion, biotransformation, and drug–drug interaction potential. Clin Pharmacokinet. 2018;57:1001–15. https://doi.org/10.1007/s40262-017-0607-4.
4. Chattopadhyay N, Kanacher T, Casjens M, Frechen S, Ligges S, Zimmermann T, et al. CYP3A4-mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1-mediated effects on bilirubin glucuronidation in humans. Br J Clin Pharmacol. 2018;84:2857–66. https://doi.org/10.1111/bcp.13750.
5. Liu H, Jiang J, Chen Z, Zhang Y, Li J, Hoechel J, et al. Pharmacokinetics and safety of the selective progesterone receptor modulator vilaprisan in Chinese healthy postmenopausal women. Clin Pharmacol Drug Dev. 2020. https://doi.org/10.1002/cpdd.851.
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