Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples-Reference-Cited by-同舟云学术

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Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples

Published:2018-04-19 Issue:3 Volume:15 Page:742-750
ISSN:1933-7213
Container-title:Neurotherapeutics
language:en
Short-container-title:Neurotherapeutics

Author:

Ugarte Ana,Corbacho David,Aymerich María S.,García-Osta Ana,Cuadrado-Tejedor Mar,Oyarzabal Julen

Funder

Foundation of Applied Medical Research (FIMA), University of Navarra

MINECO, Torre-Quevedo grant

ISCIII-FEDER

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Neurology (clinical),Pharmacology

Link

http://link.springer.com/article/10.1007/s13311-018-0624-5/fulltext.html

Reference37 articles.

1. Rankovic, Z. (2015) CNS drug design: balancing physicochemical properties for optimal brain exposure. J. Med. Chem. 58, 2584–2608.

2. Mensch, J.; Oyarzabal, J.; Mackie, C.; Augustijns, P. (2009) In vivo, in vitro and in silico methods for small molecule transfer across the BBB. J. Pharm. Sci. 98, 4429–4468.

3. Liu, X., Smith, B. J., Chen, C., Callegari, E., Becker, S. L., Chen, X., Cianfrogna, J., Doran, A. C., Doran, S. D., Gibbs, J. P., Hosea, N., Liu, J., Nelson, F. R., Szewc, M. A., and Van Deusen, J. (2006) Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration. Drug Metab. Dispos. 34, 1443–1447.

4. Hammarlund-Udenaes, M., Friden, M., Syvaenen, S., and Gupta, A. (2008) On the rate and extent of drug delivery to the brain. Pharm. Res. 25, 1737–1750.

5. Lin, J. H. (2008) CSF as a surrogate for assessing CNS exposure: An industrial perspective. Curr. Drug Metab. 9, 46–59.

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