Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-41828-4.pdf
Reference63 articles.
1. Scott, T. J., O’Connor, A. C., Link, A. N. & Beaulieu, T. J. Economic analysis of opportunities to accelerate Alzheimer’s disease research and development. Ann N Y Acad Sci 1313, 17–34, https://doi.org/10.1111/nyas.12417 (2014).
2. Mehta, D., Jackson, R., Paul, G., Shi, J. & Sabbagh, M. Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010–2015. Expert Opinion on Investigational Drugs 26, 735–739, https://doi.org/10.1080/13543784.2017.1323868 (2017).
3. Cummings, J. et al. Drug development in Alzheimer’s disease: the path to 2025. Alzheimers Res Ther 8, 39, https://doi.org/10.1186/s13195-016-0207-9 (2016).
4. Butlen-Ducuing, F. et al. Regulatory watch: Challenges in drug development for central nervous system disorders: a European Medicines Agency perspective. Nat Rev Drug Discov 15, 813–814, https://doi.org/10.1038/nrd.2016.237 (2016).
5. Hammarlund-Udenaes, M. Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations? Basic Clin Pharmacol Toxicol 106, 215–220, https://doi.org/10.1111/j.1742-7843.2009.00517.x (2010).
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