In-vitro cytotoxic and genotoxic effects of arsenic trioxide on human leukemia (HL-60) cells using the MTT and alkaline single cell gel electrophoresis (Comet) assays

Author:

Yedjou Clement G.,Tchounwou Paul B.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Reference34 articles.

1. NRC (1999) Arsenic in drinking water. U.S. National Research Council, National Academy Press. Washington, DC

2. IPCS (2001) Arsenic and arsenic compounds. World Health Organization, International Programme on Chemical Safety (Environmental Health Criteria 224). Geneva

3. Chen GQ, Zhu J, Shi XG, Ni HJ, Zhong HJ, Si GY, Jin XL, Tang W, Li XS, Xong SM, Shen ZX, Sun GL, Ma J, Zhang P, Zhang TD, Gazin C, Naoe T, Chen ST, Wang ZY, Chen Z (1996) In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: arsenic trioxide induces NB 4 cell apoptosis with down-regulation of bcl-2 expression and modulation of PML-RAR α/PML proteins. Blood 88:1052–1061

4. Rousselot P, Labaume S, Marolleau JP, Larghero J, Noguera MK, Brouet JC, ermand JP (1999) Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. Cancer Res 59:1041–1048

5. Zhang K, Ohnishi K, Shigeno, Fujisawa S, Naito K, Nakamura S, Takeshita K, akeshita A, Ohno R (1998) The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms. Leukemia 12:1383–1391

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