Kinetic Design for Establishing Long-Term Stationary Cytosol Concentrations During Drug Transport across P-gp Expressing Confluent Cell Monolayers to Facilitate Measuring Cytosol Concentration, Fitting Drug Molar Partition Coefficients into the Cytosolic Monolayer of the Plasma Membrane, and Kinetically Identifying Drug Uptake Transporters
Reference38 articles.
1. Heikkinen AT, Korjamo T, Mönkkönen J (2009) Modelling of drug disposition kinetics in in vitro intestinal absorption cell models. J Basic Clin Pharmacology & Toxicology 106:180–188 2. Zamek-Gliszczynski MJ, Lee CA, Poirier A, Bentz J, Chu X, Ellens H, Ishikawa T, Jamei M, Kalvass JC, Nagar S, Pang KS, Korzekwa K, Swaan PW, Taub ME, Zhao P, Galetin A; International Transporter Consortium (2013) ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans. Clin Pharmacol Ther 94:64–79 3. Nagar S, Argikar UA, Tweedie DJ (2014) Enzyme kinetics in drug metabolism: fundamentals and applications. Methods Mol Biol 1113:1–6. https://doi.org/10.1007/978-1-62703-758-7_1 4. Ellens H, Meng Z, Le Marchand SJ, Bentz J (2018) Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activity. Expert Opin Drug Metab Toxicol 14:571–584. https://doi.org/10.1080/17425255.2018.1480720 5. Tran TT, Mittal A, Gales T, Maleeff B, Aldinger T, Polli JW, Ayrton A, Ellens H, Bentz J (2004) Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier. J Pharm Sci 93(8):2108–2123
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