Protection against fludarabine neurotoxicity in leukemic mice by the nucleoside transport inhibitor nitrobenzylthioinosine

Author:

Adjei Alex A.,Dagnino Lina,Wong May M. Y.,Paterson Alan R. P.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference32 articles.

1. Avramis VI, Plunkett W (1982) Metabolism and therapeutic efficacy of 9-?-d-arabinofuranosyl-2-fluoroadenine against murine leukemia P388. Cancer Res 42:2587?2591

2. Barrueco JR, Jacobsen DM, Chang C-H, Brockman RW, Sirotnak FM (1987) Proposed mechanism of therapeutic selectivity for 9-?-d-arabinofuranosyl-2-fluoroadenine against murine leukemia based on lower capacities for transport and phosphorylation in proliferative intestinal epithelium compared to tumor cells. Cancer Res 47:700?706

3. Belt JA, Noel LD (1988) Isolation and characterization of a mutant of L1210 murine leukemia deficient in nitrobenzylthioinosine-insensitive nucleoside transport. J Biol Chem 263:13819?13822

4. Brockman RW, Schabel FM Jr, Montgomery JA (1977) Biologic activity of 9-?-d-arabinofuranosyl-2-fluoroadenine, a metabolically stable analog of 9-?-d-arabinofuranosyladenine. Biochem Pharmacol 26:2193?2196

5. Cass CE, Muzik H, Paterson ARP (1975) Combination therapy of mouse leukemia L1210 by cytosine arabinoside (ara-C) and nitrobenzylthioinosine. Cancer Res 35:1187?1193

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