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H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

  • Published:2017-04-11 Issue:3 Volume:134 Page:507-516
  • ISSN:0001-6322
  • Container-title:Acta Neuropathologica
  • language:en
  • Short-container-title:Acta Neuropathol

Author:

Korshunov Andrey,Schrimpf Daniel,Ryzhova Marina,Sturm Dominik,Chavez Lukas,Hovestadt Volker,Sharma Tanvi,Habel Antje,Burford Anna,Jones Chris,Zheludkova Olga,Kumirova Ella,Kramm Christof M.,Golanov Andrey,Capper David,von Deimling Andreas,Pfister Stefan M.,Jones David T. W.

Funder

Deutsche Krebshilfe

Bundesministerium für Bildung und Forschung

Deutsches Konsortium für Translationale Krebsforschung

Deutsches Krebsforschungszentrum

National Institute for Health Research

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Clinical Neurology,Pathology and Forensic Medicine

Reference34 articles.

1. Arrondeau J, Huillard O, Tlemsani C, Cessot A, Boudou-Rouquette P, Blanchet B, Thomas-Schoemann A, Vidal M, Tigaud JM, Durand JP et al (2015) Investigational therapies up to Phase II which target PDGF receptors: potential anti-cancer therapeutics. Expert Opin Investig Drugs 24:673–687. doi: 10.1517/13543784.2015.1005736

2. Bady P, Sciuscio D, Diserens AC, Bloch J, van den Bent MJ, Marosi C, Dietrich PY, Weller M, Mariani L, Heppner FL et al (2012) MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status. Acta Neuropathol 124:547–560. doi: 10.1007/s00401-012-1016-2

3. Bender S, Gronych J, Warnatz HJ, Hutter B, Groebner S, Ryzhova M, Pfaff E, Hovestadt V, Weinberg F, Halbach S et al (2016) Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. Nat Med 22:1314–1320. doi: 10.1038/nm.4204

4. Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, Morrison A, Lewis P, Bouffet E, Bartels U et al (2014) Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet 46:451–456. doi: 10.1038/ng.2936

5. Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pages M, Taylor KR, Saulnier P, Lacroix L et al (2015) Histone H3F3A and HIST1H3B K27 M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol 130:815–827. doi: 10.1007/s00401-015-1478-0
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