A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
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Published:2019-05-26
Issue:2
Volume:138
Page:237-250
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ISSN:0001-6322
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Container-title:Acta Neuropathologica
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language:en
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Short-container-title:Acta Neuropathol
Author:
van der Lee Sven J.ORCID, , Conway Olivia J., Jansen Iris, Carrasquillo Minerva M., Kleineidam Luca, van den Akker Erik, Hernández Isabel, van Eijk Kristel R., Stringa Najada, Chen Jason A., Zettergren Anna, Andlauer Till F. M.ORCID, Diez-Fairen Monica, Simon-Sanchez Javier, Lleó Alberto, Zetterberg Henrik, Nygaard Marianne, Blauwendraat Cornelis, Savage Jeanne E., Mengel-From Jonas, Moreno-Grau Sonia, Wagner Michael, Fortea Juan, Keogh Michael J., Blennow Kaj, Skoog Ingmar, Friese Manuel A., Pletnikova Olga, Zulaica Miren, Lage Carmen, de Rojas Itziar, Riedel-Heller Steffi, Illán-Gala Ignacio, Wei Wei, Jeune Bernard, Orellana Adelina, Then Bergh Florian, Wang Xue, Hulsman Marc, Beker Nina, Tesi NiccoloORCID, Morris Christopher M., Indakoetxea Begoña, Collij Lyduine E., Scherer Martin, Morenas-Rodríguez Estrella, Ironside James W., van Berckel Bart N. M., Alcolea Daniel, Wiendl Heinz, Strickland Samantha L., Pastor Pau, Rodríguez Rodríguez Eloy, Boeve Bradley F., Petersen Ronald C., Ferman Tanis J., van Gerpen Jay A., Reinders Marcel J. T., Uitti Ryan J., Tárraga Lluís, Maier Wolfgang, Dols-Icardo Oriol, Kawalia Amit, Dalmasso Maria Carolina, Boada Mercè, Zettl Uwe K., van Schoor Natasja M., Beekman Marian, Allen Mariet, Masliah Eliezer, de Munain Adolfo López, Pantelyat Alexander, Wszolek Zbigniew K., Ross Owen A., Dickson Dennis W., Graff-Radford Neill R., Knopman David, Rademakers Rosa, Lemstra Afina W., Pijnenburg Yolande A. L., Scheltens PhilipORCID, Gasser Thomas, Chinnery Patrick F, Hemmer Bernhard, Huisman Martijn A., Troncoso Juan, Moreno Fermin, Nohr Ellen A., Sørensen Thorkild I. A., Heutink Peter, Sánchez-Juan Pascual, Posthuma Danielle, Clarimón Jordi, Christensen Kaare, Ertekin-Taner Nilüfer, Scholz Sonja W., Ramirez Alfredo, Ruiz Agustín, Slagboom Eline, van der Flier Wiesje M., Holstege HenneORCID, , , , , ,
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Clinical Neurology,Pathology and Forensic Medicine
Reference60 articles.
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https://doi.org/10.1016/j.neurobiolaging.2013.09.017 3. Broce I, Karch CM, Wen N, Fan CC, Wang YP, Tan CH et al (2018) Immune-related genetic enrichment in frontotemporal dementia: an analysis of genome-wide association studies. Plos Med.
https://doi.org/10.1371/journal.pmed.1002487 4. Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL et al (2015) GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci 70:110–118.
https://doi.org/10.1093/gerona/glu166 5. Chae JJ, Park YH, Park C, Hwang IY, Hoffmann P, Kehrl JH et al (2015) Connecting two pathways through Ca2+ signaling: NLRP3 inflammasome activation induced by a hypermorphic PLCG2 mutation. Arthritis Rheumatol 67:563–567.
https://doi.org/10.1002/art.38961
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