Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta
-
Published:2022-02-23
Issue:5
Volume:15
Page:1075-1085
-
ISSN:1937-5387
-
Container-title:Journal of Cardiovascular Translational Research
-
language:en
-
Short-container-title:J. of Cardiovasc. Trans. Res.
Author:
de Vecchi Adelaide, Faraci Alessandro, Fernandes Joao Filipe, Marlevi David, Bellsham-Revell Hannah, Hussain Tarique, Laji Nidhin, Ruijsink Bram, Wong James, Razavi Reza, Anderson David, Salih Caner, Pushparajah Kuberan, Nordsletten David, Lamata PabloORCID
Abstract
AbstractAortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions.
Graphical abstract
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Cardiology and Cardiovascular Medicine,Pharmaceutical Science,Genetics,Molecular Medicine
Reference33 articles.
1. Safar, M. E. (2020). Current assessment of pulse wave velocity: Comprehensive review of validation studies. Journal of Hypertension, 38(1), 178. https://doi.org/10.1097/HJH.0000000000002261 2. Gruber, P. J., & Spray, T. L. (2014). Surgical approaches to the hypoplastic left heart syndrome. In Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care (pp. 1788–1808). https://doi.org/10.1007/978-1-4471-4619-3 3. Biglino, G., Schievano, S., Steeden, J. A., Ntsinjana, H., Baker, C., Khambadkone, S., … Giardini, A. (2012). Reduced ascending aorta distensibility relates to adverse ventricular mechanics in patients with hypoplastic left heart syndrome: Noninvasive study using wave intensity analysis. The Journal of thoracic and cardiovascular surgery, 144(6), 1307–13. https://doi.org/10.1016/j.jtcvs.2012.08.028 4. Schlangen, J., Fischer, G., Petko, C., Hansen, J. H., Voges, I., Rickers, C., & Uebing, A. (2013). Arterial elastance and its impact on intrinsic right ventricular function in palliated hypoplastic left heart syndrome. International Journal of Cardiology, 168(6), 5385–5389. https://doi.org/10.1016/J.IJCARD.2013.08.052 5. Lloyd, D. F. A., Rutherford, M. A., Simpson, J. M., & Razavi, R. (2017). The neurodevelopmental implications of hypoplastic left heart syndrome in the fetus. Cardiology in the Young, 27(2), 217–223. https://doi.org/10.1017/S1047951116001645
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|