Quantitative Coronary Physiology for Clinical Management: the Imaging Standard

Author:

Gould K. Lance,Johnson Nils P.

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Reference55 articles.

1. Johnson NP, Tóth GG, Lai D, Zhu H, Açar G, Agostoni P, et al. Prognostic value of fractional flow reserve: linking physiologic severity to clinical outcomes. J Am Coll Cardiol. 2014;64:1641–54. From a large database establishes statistically the severity-risk-benefit continuum of CAD having profound implications for the imaging standard of quantifying severity and personalized management.

2. Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, et al. Global coronary flow reserve associates with adverse cardiovascular events independently of luminal angiographic severity, and modifies. The effect of early revascularization. Circulation. 2015;131:19–27. Documents CFR thresholds for high, intermediate and low risk global diffuse CAD.

3. Gould KL, Johnson NP, Kaul S, Kirkeeide RL, Mintz GS, Rentrop KP, et al. Patient selection for elective revascularization to reduce myocardial infarction and mortality: new lessons from randomized trials, coronary physiology, and statistics. Circ Cardiovasc Imaging. 2015;8, e003099. doi: 10.1161/CIRCIMAGING.114.003099 . Establishes basic concepts and clinical implications of the severity-risk-benefit continuum to explain failure of randomized intervention trials to reduce risk of MI or mortality and criteria for patient selection clinically and for future trials to demonstrate improved event free survival.

4. Johnson NP, Gould KL. Physiologic basis for angina and ST change: PET-verified thresholds of quantitative stress myocardial perfusion and coronary flow reserve. J Am Coll Cardiol Img. 2011;4:990–8.

5. Johnson NP, Gould KL. Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiologic severity. J Am Coll Cardiol Img. 2012;5:430–40. Reports the concept of Coronary Flow Capacity to define physiologic severity of CAD that incorporates stress flow in cc/min/gm and CFR thereby accounting for the great heterogeneity of continuous values into a simple color coded evidences based schema for interventional and management decisions.

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