Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice-Reference-Cited by-同舟云学术

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Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice

Published:2017-01-24 Issue:2 Volume:368 Page:379-387
ISSN:0302-766X
Container-title:Cell and Tissue Research
language:en
Short-container-title:Cell Tissue Res

Author:

Hoshi Hiroko,Akagi Ryuichiro,Yamaguchi Satoshi,Muramatsu Yuta,Akatsu Yorikazu,Yamamoto Yohei,Sasaki Toshihide,Takahashi Kazuhisa,Sasho Takahisa

Funder

MS & AD Insurance group

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Histology,Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00441-016-2563-y.pdf

Reference28 articles.

1. Aigner T, Zien A, Hanisch D, Zimmer R (2003) Gene expression in chondrocytes assessed with use of microarrays. J Bone Joint Surg Am 85-A:117–123

2. Akagi R, Sasho T, Saito M, Endo J, Yamaguchi S, Muramatsu Y, Mukoyama S, Akatsu Y, Katsuragi J, Fukawa T, Takahashi K (2014) Effective knockdown of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model. J Orthop Res 32:1175–1180

3. Blanco FJ (2014) Osteoarthritis year in review 2014: we need more biochemical biomarkers in qualification phase. Osteoarthritis Cartilage 22:2025–2032

4. Burrage PS, Brinckerhoff CE (2007) Molecular targets in osteoarthritis: metalloproteinases and their inhibitors. Curr Drug Targets 8:293–303

5. Chu X, You H, Yuan X, Zhao W, Li W, Guo X (2013) Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis. Int J Mol Med 31:1222–1228

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