Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model
Author:
Affiliation:
1. Department of Orthopaedic Surgery; Graduate School of Medicine; Chiba University; 1-8-1 Inohana Chuo-ku Chiba Chiba 260-8670 Japan
Publisher
Wiley
Subject
Orthopedics and Sports Medicine
Reference22 articles.
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2. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development;Little;Arthritis Rheum,2009
3. Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats;Renkiewicz;Arthritis Rheum,2003
4. A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models;Baragi;Arthritis Rheum,2009
5. Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes;Settle;Arthritis Rheum,2010
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