Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir

Author:

Kirby Brian J.,Symonds William T.,Kearney Brian P.,Mathias Anita A.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference37 articles.

1. SOVALDI® (sofosbuvir) tablets, for oral use. US prescribing information [revised]. Foster City: Gilead Sciences, Inc.; 2014.

2. HARVONI® (ledipasvir and sofosbuvir) tablets, for oral use. US prescribing information. Foster City: Gilead Sciences, Inc.; 2014.

3. Murakami E, Tolstykh T, Bao H, Niu C, Steuer HM, Bao D, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010;285(45):34337–47. doi: 10.1074/jbc.M110.161802 .

4. Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 1995;12(3):413–20.

5. Babusis D, Curry MP, Denning J, Wang T, Kirby B, Murakami E, et al. Translational studies to understand the mechanism of liver delivery by sofosbuvir [oral presentation]. 15th International Workshop on Clinical Pharmacology of HIV and Hepatitis Therapy; 19–21 May 2014; Washington, DC.

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