Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus-Reference-Cited by-同舟云学术

Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus

Published:2023-07-18 Issue:7 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Martínez-González Brenda¹²,Gallego Isabel³,Gregori Josep⁴,Soria María Eugenia¹²,Somovilla Pilar³⁵,de Ávila Ana Isabel³,García-Crespo Carlos³,Durán-Pastor Antoni¹,Briones Carlos⁶^ORCID,Gómez Jordi⁷,Quer Josep⁴⁸⁹,Domingo Esteban³^ORCID,Perales Celia¹²^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

2. Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Madrid, Spain

3. Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

4. Liver Diseases-Viral Hepatitis, Liver Unit, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain

5. Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, Spain

6. Centro de Astrobiología (CAB, CSIC-INTA), Madrid, Spain

7. Instituto de Parasitología y Biomedicina ‘López-Neyra’ (CSIC), Parque Tecnológico Ciencias de la Salud, Granada, Spain

8. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain

9. Biochemistry and Molecular Biology Department, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain

Abstract

The concept of a mild mutagen was coined to describe a minor mutagenic activity exhibited by some nucleoside analogues that potentiated their efficacy as antiretroviral agents. In the present study, we report the mild mutagen activity of sofosbuvir (SOF) for hepatitis C virus (HCV).

Funder

Ministerio de Economía y Competitividad

Ministerio de Ciencia, Innovación y Universidades

Fundación La Marató

Ministerio de Ciencia e Innovación

MEC | Instituto de Salud Carlos III

Comunidad de Madrid

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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