Author:
Courcelles Eulalie,Horner Marc,Afshari Payman,Kulesza Alexander,Curreli Cristina,Vaghi Cristina,Morales-Orcajo Enrique,Pappalardo Francesco,Maquer Ghislain,Russo Giulia,Geris Liesbet,Viceconti Marco,Neidlin Michael,Favre Philippe,Lesage Raphaëlle,Kreuzer Steve,Carbone Vincenzo
Abstract
AbstractThe need for a framework to justify that a model has sufficient credibility to be used as a basis for internal or external (typically regulatory) decision-making is a primary concern when using modelling and simulation (M&S) in healthcare. This chapter reviews published standards on verification, validation, and uncertainty quantification (VVUQ) as well as regulatory guidance that can be used to establish model credibility in this context, providing a potential starting point for a globally harmonised model credibility framework.
Publisher
Springer Nature Switzerland