Epigenetics in lymphocyte and lymphoma: EZH2 as an easy-to-access therapeutic target?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Hematology
Link
https://link.springer.com/content/pdf/10.1007/s12185-022-03472-z.pdf
Reference10 articles.
1. Cao R, Wang L, Wang H, et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science. 2002;298:1039–43. https://doi.org/10.1126/science.1076997.
2. Morschhauser F, Tilly H, Chaidos A, et al. Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial. Lancet Oncol. 2020;21:1433–42. https://doi.org/10.1016/S1470-2045(20)30441-1.
3. Fujikawa D, Nakagawa S, Hori M, et al. Polycomb-dependent epigenetic landscape in adult T-cell leukemia. Blood. 2016;127:1790–802. https://doi.org/10.1182/blood-2015-08-662593.
4. Yamagishi M, Hori M, Fujikawa D, et al. Targeting excessive EZH1 and EZH2 activities for abnormal histone methylation and transcription network in malignant lymphomas. Cell Rep. 2019;29:2321-2337.e7. https://doi.org/10.1016/j.celrep.2019.10.083.
5. Ennishi D, Takata K, Béguelin W, et al. Molecular and genetic characterization of MHC deficiency identifies EZH2 as therapeutic target for enhancing immune recognition. Cancer Discov. 2019;9:546–63. https://doi.org/10.1158/2159-8290.CD-18-1090.
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