Polycomb-dependent epigenetic landscape in adult T-cell leukemia-Reference-Cited by-同舟云学术

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Published:2016-04-07 Issue:14 Volume:127 Page:1790-1802
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fujikawa Dai¹,Nakagawa Shota¹,Hori Makoto¹,Kurokawa Naoya¹,Soejima Ai¹,Nakano Kazumi¹,Yamochi Tadanori¹,Nakashima Makoto¹,Kobayashi Seiichiro²,Tanaka Yuetsu³,Iwanaga Masako⁴,Utsunomiya Atae⁵,Uchimaru Kaoru²,Yamagishi Makoto¹,Watanabe Toshiki¹

Affiliation:

1. Graduate School of Frontier Sciences, Department of Computational Biology and Medical Sciences, and

2. Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

3. Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa, Japan;

4. Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; and

5. Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan

Abstract

Key PointsATL involves genome-wide reprogramming of the H3K27me3 pattern that is distinct from other cell types. Druggable epigenetic mechanisms are associated with ATL cell development and HTLV-1–mediated transformation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/14/1790/1392892/1790.pdf

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