An extended pharmacokinetic/pharmacodynamic model describing quantitatively the influence of plasma protein binding, tissue binding, and receptor binding on the potency and time course of action of drugs-Reference-Cited by-同舟云学术

An extended pharmacokinetic/pharmacodynamic model describing quantitatively the influence of plasma protein binding, tissue binding, and receptor binding on the potency and time course of action of drugs

Published:1996-01-30 Issue:1 Volume:24 Page:45-77
ISSN:0090-466X
Container-title:Journal of Pharmacokinetics and Biopharmaceutics
language:en
Short-container-title:Journal of Pharmacokinetics and Biopharmaceutics

Author:

Proost Johannes H.,Wierda J. Mark K. H.,Meijer Dirk K. F.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/BF02353510.pdf

Reference29 articles.

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3. P. Dusouich, J. Verges, and S. Erill. Plasma protein binding and pharmacological response.Clin. Pharmacokin. 24:435–440 (1993).

4. L. B. Sheiner, D. R. Stanski, S. Vozeh, R. D. Miller, and J. Ham. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine.Clin. Pharmacol. Ther. 25:358–371 (1979).

5. J. H. Proost, J. M. K. H. Wierda, and D. K. F. Meijer. Pharmacokinetic/pharmacodynamic modeling in the development of new short-acting neuromuscular blocking agents. InMeasurement and Kinetics of In Vivo Drug Effects—Advances in Simultaneous Pharmacokinetic/Pharmacodynamic Modelling, Center for Bio-Pharmaceutical Sciences, Leiden University, 1990, pp. 50–51.

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