Synthesis and anti-inflammatory activity of novel pyridazine and pyridazinone derivatives as non-ulcerogenic agents

Author:

Saeed Makarem M.,Khalil Nadia A.,Ahmed Eman M.,Eissa Kholoud I.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Drug Discovery,Molecular Medicine

Reference36 articles.

1. Abdel-Hakeem, M., Synthesis, anti-inflammatory and analgesic activities of new 6-(4-fluorophenyl)pyridazines. Bull. Fac. Pharm. Cairo Univ., 42, 19–30 (2004).

2. Abouzid, K., Frohberg, P., Lehmann, J., and Decker, M., 6-Aryl-4-oxohexanoic acids: Synthesis, effects on eicosanoid biosynthesis, and anti-inflammatory in vivo-activities. Med. Chem., 3, 433–438 (2007).

3. Abouzid, K. and Bekhit, S. A., Novel anti-inflammatory agents based on pyridazinone scaffold; design, synthesis and in vivo activity. Bioorg. Med. Chem., 16, 5547–5556 (2008).

4. Abouzid, K., Khalil, N. A., Ahmed, E. M., and Abd El-Latif, H. A., Design, Synthesis and anti-inflammatory activity of 3-arylethenyl-6-substituted-pyridazines. Bull. Fac. Pharm. Cairo Univ., 46, 269–276 (2008).

5. Akbas, E. and Berber, I., Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives. Eur. J. Med. Chem., 40, 401–405 (2005).

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