The Impact of Incorporation Piperazine on Biological Activities of Benzazoles

Author:

Al-Harthy Thuraya,Zoghaib Wajdi,Abdel-Jalil Raid

Abstract

Heterocycles are widely distributed compounds in natural products and are involved in many biological processes. Its uses have been extended to different fields, including industry, medicine, and agriculture sectors. Benzazole is one of the popular heterocycle scaffolds known as a privilege structure which is commonly found in many pharmaceutical agents. Another outstanding scaffold is piperazine that is known as a distinguishable motif in drug design with a wide range of biological activities. One of the fruitful approaches in the drug design is a hybridization of privilege structures in one skeleton which are believed to grant a characteristic feature with improved or more selective biological activities than the two scaffolds. The effect that piperazine imparted while introduced into a benzazole has drawn attention since first used in the nineteenth century. Numerous research has been performed discussing the synthesis and biological activities of benzazoles containing piperazine. In this chapter, we will highlight a general introduction about chemistry and structure of piperazine, and its importance in medicinal chemistry and benzazole as well. Next, several studies will be discussed that highlight the importance of incorporating piperazine in benzazole skeletons, benzimidazole, benzothiazole, and benzoxazole, and biological activity inherited from this combination.

Publisher

IntechOpen

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3