Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC
Author:
Funder
Natural Science Foundation of Shaanxi Province
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Drug Discovery,Molecular Medicine
Link
https://link.springer.com/content/pdf/10.1007/s12272-023-01471-0.pdf
Reference34 articles.
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2. Beck H, Härter M, Haß B, Schmeck C, Baerfacker L (2022) Small molecules and their impact in drug discovery: a perspective on the occasion of the 125th anniversary of the Bayer chemical research laboratory. Drug Discov Today 27:1560–1574. https://doi.org/10.1016/j.drudis.2022.02.015
3. Boopathy GTK, Lynn JLS, Wee S, Gunaratne J, Hong W (2018) Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines. Cell Signal 43:21–31. https://doi.org/10.1016/j.cellsig.2017.11.006
4. Campagne O, Yeo KK, Fangusaro J, Stewart CF (2021) Clinical pharmacokinetics and pharmacodynamics of selumetinib. Clin Pharmacokinet 60:283–303. https://doi.org/10.1007/s40262-020-00967-y
5. Carvajal RD, Piperno-Neumann S, Kapiteijn E, Chapman PB, Frank S, Joshua AM (2018) Selumetinib in combination with dacarbazine in patients with metastatic uveal melanoma: a phase III, multicenter, randomized trial (SUMIT). J Clin Oncol 36:1232–1239. https://doi.org/10.1200/JCO.2017.74.1090
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