Transient responses of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture

Author:

Miller W. M.,Wilke C. R.,Blanch H. W.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Bioengineering,Biotechnology,Applied Microbiology and Biotechnology,Biotechnology

Reference21 articles.

1. Eigenbrodt, E.; Fister, P.; Reinacher, M.: New perspectives on carbohydrate metabolism in tumor cells. In: Beitner, R. (Ed.): Regulation of carbohydrate metabolism vol. 2, pp. 141?179. Boca Raton, FL: CRC Press 1985

2. McKeehan, W. L.: Glutaminolysis in animal cells. In: Morgan, M. J. (Ed.): Carbohydrate metabolism in cultured cells, pp. 111?150. New York: Plenum Press 1986

3. Butler, M.; Spier, R. E.: The effects of glutamine utilisation and ammonia production on the growth of BHK cells in microcarrier cultures. J. Biotechnol. 1 (1984) 187?196

4. Glacken, M. W.; Fleischaker, R. J.; Sinskey, A. J.: Reduction of waste product excretion via nutrient control: possible stategies for maximizing product and cell yields on serum in cultures of mammalian cells. Biotechnol. Bioeng. 28 (1986) 1376?1389

5. Miller, W. M.; Wilke, C. R.; Blanch, H. W.: The transient responses of hybridoma cells to nutrient additions in continuous culture: II. glutamine pulse and step changes. Submitted to Biotechnol. Bioeng. 1987

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