Abstract
AbstractNew spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine derivatives (3–23) were investigated. Then there is in vitro antimicrobial potency against possible organisms Staphylococcus aurous ATCC-47,077, Bacillus cereus ATCC-12228, Escherichia coli ATCC-25922, Salmonella typhiATCC-15566, and Candida albicans ATCC-10231 were tested utilizing commercially available antibiotics ampicillin as a reference drug. A preliminary antimicrobial test represented that derivatives: (Aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-(p-tolyl)-3'H-spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile (16–19) and (Acetyl aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-(p-tolyl)-3'H-spiro [cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile (20–23) exhibited higher antifungal, and antibacterial performance with minimum inhibitory concentrations values of (39–67 µg/ml) toward all pathogenic strains compared to common reference drug ampicillin.
Funder
National Research Centre Egypt
Publisher
Springer Science and Business Media LLC
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