Cyclic peptide analogs of 558–565 epitope of A2 subunit of Factor VIII prolong aPTT. Toward a novel synthesis of anticoagulants

Author:

Anastasopoulos C.,Sarigiannis Y.,Stavropoulos G.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Clinical Biochemistry,Biochemistry

Reference37 articles.

1. Anastasopoulos C, Sarigiannis Y, Stavropoulos G (2010) Synthesis of peptide analogs of the A2 subunit (sequence 558–565) of the factor VIIIa of blood coagulation. In: Peptides 2010: proceedings of the 31st European Peptide Symposium. Copenhagen, Denmark, pp 364–365

2. Anastasopoulos C, Sarigiannis Y, Stavropoulos G (2012) Design, synthesis and biological evaluation of cyclic peptide analogs of the A2 subunit (sequence 558–565) of the factor VIII of blood coagulation. In: Peptides 2012 proceedings of the 32nd European Peptide Symposium. Athens, Greece, pp 266–267

3. Anastasopoulos C, Sarigiannis Y, Stavropoulos G (2013) A novel approach in potential anticoagulants from peptides epitope 558–565 of A2 subunit of factor VIII. Amino Acids 44:1159–1165

4. Baeriswyl V, Calzavarini S, Gerschheimer C, Diderich Ph, Angelillo-Scherrer A, Heinis Ch (2013) Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy. J Med Chem 56:3742–3746

5. Bajaj P, Schmidt A, Mathur A, Padmanabhan K, Zhong D, Mastrii M, Fay P (2001) Factor IXa:Factor VIIIa interaction. J Biol Chem 276:16302–16309

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