Cytosolic/microsomal redox pathway: a reductive retention mechanism of a PET-oncology tracer, Cu-pyruvaldehyde-bis(N 4-methylthiosemicarbazone) (Cu-PTSM)

Author:

Shibuya Keiko,Fujibayashi Yasuhisa,Yoshimi Eiji,Sasai Keisuke,Hiraoka Masahiro,Welch Michel J.

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

Reference30 articles.

1. Fujibayashi Y, Matsumoto K, Yonekura Y, Konishi J, Yokoyama A. A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals.J Nucl Med 30: 1838–1842, 1989.

2. Fujibayashi Y, Wada K, Taniuchi H, Yonekura Y, Konishi J, Yokoyama A. Mitochondria-selective reduction of62Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (62Cu-PTSM) in the murine brain; a novel radiopharmaceutical for brain positron emission tomography (PET) imaging.Biol Pharm Bull 16: 146–149, 1993.

3. Matsumoto K, Fujibayashi Y, Yonekura Y, Wada K, Takemura Y, Konishi J, et al. Application of the new zinc-62/copper-62 generator: an effective labeling method for62Cu-PTSM.Nucl Med Biol 19: 39–44, 1992.

4. Okazawa H, Yonekura Y, Fujibayashi Y, Nishizawa S, Magata Y, Ishizu K, et al. Clinical application and quantitative evaluation of generator-produced copper-62-PTSM as a brain perfusion tracer for PET.J Nucl Med 35: 1910–1915, 1994.

5. Wada K, Fujibayashi Y, Taniuchi H, Tajima N, Tamaki N, Konishi J, et al. Effects of ischemia-reperfusion injury on myocardial single pass extraction and retention of Cu-PTSM in perfused rat hearts: comparison with201T1 and14C-iodoantipyrine.Nucl Med Biol 21: 613–617, 1994.

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