Affiliation:
1. Department of Nuclear Medicine, Saarland University – Medical Center 66421 Homburg Germany
2. Department of Oncology, Karmanos Cancer Institute, Wayne State University Detroit MI 48202 USA
3. Department of Chemistry, 111 College Place, Syracuse University Syracuse NY 13244 USA rpdoyle@syr.edu jazubiet@syr.edu
Abstract
Molecular imaging is an expansive and rapidly growing field. Metallic elements such as 67Ga, 68Ga, 99mTc, 111In, 64Cu, 86Y, 89Zr are accessible radioisotopes that can be incorporated into diagnostic imaging agents for single photon emission computed tomography (SPECT), or positron emission tomography (PET). The role of the coordination chemistry of the metals is crucial in designing appropriate ligands for the development of new and more effective probes. This article highlights the fundamental coordination chemistries of radiometals that are currently of interest for radio-pharmaceutical design. This subtle interplay of coordination chemistry, multi-functional chelate design, and radiopharmaceutical development is illustrated through four specific examples from our own work: (1) single amino acid chelates (SAACs) for the design of labeled radioconjugates, (2) vitamin B12-based imaging agents, (3) novel PET agents based on 89Zr and (4) developments in PET imaging based on the coordination chemistries of copper and gallium.
Publisher
The Royal Society of Chemistry