The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization

Author:

Zeng Mingbing,Shen Jikui,Liu Yuanyuan,Lu Lucy Yang,Ding Kun,Fortmann Seth D.,Khan Mahmood,Wang Jiangxia,Hackett Sean F.,Semenza Gregg L.,Campochiaro Peter A.

Funder

National Eye Institute

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Drug Discovery,Molecular Medicine

Reference46 articles.

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2. Klein R, Klein B (1995) Vision disorders in diabetes. In: Group NDD (ed) Diabetes in America National Institutes of Health. Washington, D.C., pp. 293–330

3. Ozaki H, Yu A, Della N, Ozaki K, Luna JD, Yamada H, Hackett SF, Okamoto N, Zack DJ, Semenza GL et al (1999) Hypoxia inducible factor-1a is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 40:182–189

4. Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL (2003) Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93:1074–1081

5. Vinores SA, Xiao WH, Aslam S, Shen J, Oshima Y, Nambu H, Liu H, Carmeliet P, Campochiaro PA (2006) Implication of the hypoxia response element of the VEGF promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development. J Cell Physiol 206:749–758

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