Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice-Reference-Cited by-同舟云学术

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Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice

Published:2019-05-30 Issue:8 Volume:97 Page:1127-1138
ISSN:0946-2716
Container-title:Journal of Molecular Medicine
language:en
Short-container-title:J Mol Med

Author:

Boujon Valérie,Uhlemann Ria,Wegner Stephanie,Wright Matthew B.,Laufs Ulrich,Endres Matthias,Kronenberg Golo,Gertz Karen

Funder

DFG

Bundesministerium für Bildung und Forschung

DZNE

DZHK

Corona Foundation

F. Hoffmann-La Roche

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Drug Discovery,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00109-019-01801-0.pdf

Reference54 articles.

1. Dietz M, Mohr P, Kuhn B, Maerki HP, Hartman P, Ruf A, Benz J, Grether U, Wright MB (2012) Comparative molecular profiling of the PPARalpha/gamma activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. Chem Med Chem 7:1101–1111

2. Benardeau A, Benz J, Binggeli A, Blum D, Boehringer M, Grether U et al (2009) Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. Bioorg Med Chem Lett 19:2468–2473

3. Shimazu T, Inoue I, Araki N, Asano Y, Sawada M, Furuya D, Nagoya H, Greenberg JH (2005) A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke. 36:353–359

4. Pereira MP, Hurtado O, Cardenas A, Bosca L, Castillo J, Davalos A et al (2006) Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. J Cereb Blood Flow Metab 26:218–229

5. Zhao Y, Patzer A, Herdegen T, Gohlke P, Culman J (2006) Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. FASEB J 20:1162–1175

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