Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip
Author:
Funder
AstraZeneca Postdoc Programme
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00204-021-03062-8.pdf
Reference58 articles.
1. Adler M, Ramm S, Hafner M et al (2016) A quantitative approach to screen for nephrotoxic compounds in vitro. J Am Soc Nephrol 27(4):1015–1028. https://doi.org/10.1681/asn.2015010060
2. Babic JT, Manchandani P, Ledesma KR, Tam VH (2017) Evaluation of Urinary KIM-1 for Prediction of Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother 61(11). https://doi.org/10.1128/aac.01735-17
3. Bailly V, Zhang Z, Meier W, Cate R, Sanicola M, Bonventre JV (2002) Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem 277(42):39739–39748. https://doi.org/10.1074/jbc.M200562200
4. Bianchini D, Omlin A, Pezaro C et al (2013) First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer. Br J Cancer 109(10):2579–2586. https://doi.org/10.1038/bjc.2013.619
5. Burdick AD, Sciabola S, Mantena SR et al (2014) Sequence motifs associated with hepatotoxicity of locked nucleic acid–modified antisense oligonucleotides. Nucleic Acids Res 42(8):4882–4891. https://doi.org/10.1093/nar/gku142
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