Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells
Author:
Funder
Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación
Conselleria d'Educació, Investigació, Cultura i Esport
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00204-022-03236-y.pdf
Reference57 articles.
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3. Atienzar FA, Novik EI, Gerets HH et al (2014) Predictivity of dog co-culture model, primary human hepatocytes and hepg2 cells for the detection of hepatotoxic drugs in humans. Toxicol Appl Pharmacol 275(1):44–61. https://doi.org/10.1016/j.taap.2013.11.022
4. Bell CC, Lauschke VM, Vorrink SU et al (2017) Transcriptional, functional, and mechanistic comparisons of stem cell-derived hepatocytes, heparg cells, and three-dimensional human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury. Drug Metab Dispos 45(4):419–429. https://doi.org/10.1124/dmd.116.074369
5. Bell CC, Dankers ACA, Lauschke VM et al (2018) Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study. Toxicol Sci 162(2):655–666. https://doi.org/10.1093/toxsci/kfx289
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