Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes-Reference-Cited by-同舟云学术

Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes

Published:2020-01-01 Issue:2 Volume:94 Page:589-607
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Petrov Petar D.^ORCID,Fernández-Murga Leonor^ORCID,Conde Isabel,Martínez-Sena Teresa,Guzmán Carla,Castell José Vicente^ORCID,Jover Ramiro^ORCID

Funder

FP7 Health

Instituto de Salud Carlos III

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00204-019-02643-y.pdf

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3. Badolo L, Jensen B, Säll C et al (2015) Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture. Xenobiotica 45:177–187. https://doi.org/10.3109/00498254.2014.955831

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5. Ballatori N, Li N, Fang F et al (2009) OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids. Front Biosci 14:2829–2844. https://doi.org/10.2741/3416

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