Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels

Author:

Tremmel Roman,Herrmann Kristin,Engst Wolfram,Meinl Walter,Klein Kathrin,Glatt Hansruedi,Zanger Ulrich M.ORCID

Funder

Robert Bosch Stiftung (DE)

German Institute for Risk Assessment

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference34 articles.

1. Al-Subeihi AAA, Alhusainy W, Kiwamoto R, Spenkelink B, van Bladeren PJ, Rietjens IMCM, Punt A (2015) Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations. Toxicol Appl Pharmacol 283:117–126. doi: 10.1016/j.taap.2014.12.009

2. Boberg EW, Miller EC, Miller JA, Poland A, Liem A (1983) Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1′-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1′-hydroxysafrole in mouse liver. Cancer Res 43:5163–5173

3. De Vincenzi M, Silano M, Stacchini P, Scazzocchio B (2000) Constituents of aromatic plants: I. Methyleugenol. Fitoterapia 71:216–221. doi: 10.1016/S0367-326X(99)00150-1

4. Engelke CE, Meinl W, Boeing H, Glatt H (2000) Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. Pharmacogenetics 10:163–169

5. European Union (2001) Opinion of the Scientific Committee on Food on Methyleugenol (4-Allyl-1,2-dimethoxybenzene). https://ec.europa.eu/food/sites/food/files/safety/docs/sci-com_scf_out102_en.pdf . Accessed 10 Feb 2017

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