Towards better prediction of xenobiotic genotoxicity: CometChip technology coupled with a 3D model of HepaRG human liver cells
Author:
Funder
Région Bretagne
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00204-022-03292-4.pdf
Reference37 articles.
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2. Ates G, Mertens B, Heymans A et al (2018) A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment. Arch Toxicol 92:1593–1608. https://doi.org/10.1007/s00204-018-2172-5
3. Baird WM, Hooven LA, Mahadevan B (2005) Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen 45:106–114. https://doi.org/10.1002/em.20095
4. Buick JK, Williams A, Gagné R et al (2020) Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells. Genes Environ 42:1–14. https://doi.org/10.1186/s41021-019-0139-2
5. Buick JK, Williams A, Meier MJ et al (2021) A modern genotoxicity testing paradigm: integration of the high-throughput CometChip® and the TGx-DDI transcriptomic biomarker in human HepaRG™ cell cultures. Front Public Heal 9:1–19. https://doi.org/10.3389/fpubh.2021.694834
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