SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice
Author:
Funder
Jiangsu Science and Technology Department
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00204-023-03611-3.pdf
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3. Bruchard M, Mignot G, Derangère V et al (2013) Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med 19(1):57–64. https://doi.org/10.1038/nm.2999
4. Cheng B, Pan W, Xing Y, Xiao Y, Chen J, Xu Z (2022) Recent advances in DDR (DNA damage response) inhibitors for cancer therapy. Eur J Med Chem 230:114109. https://doi.org/10.1016/j.ejmech.2022.114109
5. da Costa A, Chowdhury D, Shapiro GI, D’Andrea AD, Konstantinopoulos PA (2023) Targeting replication stress in cancer therapy. Nat Rev Drug Discov 22(1):38–58. https://doi.org/10.1038/s41573-022-00558-5
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