Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth-Reference-Cited by-同舟云学术

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

Published:2012-12-02 Issue:1 Volume:19 Page:57-64
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Bruchard Mélanie,Mignot Grégoire,Derangère Valentin,Chalmin Fanny,Chevriaux Angélique,Végran Frédérique,Boireau Wilfrid,Simon Benoit,Ryffel Bernhard,Connat Jean Louis,Kanellopoulos Jean,Martin François,Rébé Cédric,Apetoh Lionel,Ghiringhelli François

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.2999.pdf

Reference45 articles.

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4. Ménard, C., Martin, F., Apetoh, L., Bouyer, F. & Ghiringhelli, F. Cancer chemotherapy: not only a direct cytotoxic effect, but also an adjuvant for antitumor immunity. Cancer Immunol. Immunother. 57, 1579–1587 (2008).

5. Ghiringhelli, F. et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors. Nat. Med. 15, 1170–1178 (2009).

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