Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis

Author:

Houshmand Fariba,Barati Mahmood,Golab Fereshteh,Ramezani-sefidar Samaneh,Tanbakooie Sara,Tabatabaei Mahsa,Amiri Masoomeh,Sanadgol NimaORCID

Funder

Shahrekord University of Medical Sciences

University of Zabol

Publisher

Springer Science and Business Media LLC

Subject

Applied Mathematics,General Mathematics

Reference49 articles.

1. Sanadgol N, Zahedani SS, Sharifzadeh M, Khalseh R, Barbari GR, Abdollahi M. Recent updates in imperative natural compounds for healthy brain and nerve function: a systematic review of implications for multiple sclerosis. Curr Drug Targets. 2017;18:1499–517.

2. Praet J, Guglielmetti C, Berneman Z, Van der Linden A, Ponsaerts P. Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis. Neurosci Biobehav Rev. 2014;47:485–505.

3. Kochanowski J, Uchman D, Litwiniuk A, et al. Assessment of plasma brain-derived neurotrophic factor (BDNF), activity-dependent neurotrophin protein (ADNP) and vasoactive intestinal peptide (VIP) concentrations in treatment-naive humans with multiple sclerosis. Neuro Endocrinol Lett. 2015;36:148–52.

4. Chaldakov GN, Tonchev AB, Aloe L. NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Riv Psichiatr. 2009;44:79–87.

5. Hristova MG. Metabolic syndrome and neurotrophins: effects of metformin and non-steroidal anti-inflammatory drug treatment. Eur J Med. 2011;43:141–5.

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