Tuning the Assembly of Bispecific Antibodies by Playing on Differential Polypeptide Chain Molar Ratios-Reference-Cited by-同舟云学术

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Tuning the Assembly of Bispecific Antibodies by Playing on Differential Polypeptide Chain Molar Ratios

Published:2023-08 Issue:4 Volume:28 Page:658-671
ISSN:1226-8372
Container-title:Biotechnology and Bioprocess Engineering
language:en
Short-container-title:Biotechnol Bioproc E

Author:

De Temmerman Célia,Bernard Pauline,Aeberli Quentin,Braito Sarah,Arib Ghislaine,Girod Pierre-Alain,Fagète Séverine

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://link.springer.com/content/pdf/10.1007/s12257-023-0057-9.pdf

Reference44 articles.

1. Labrijn, A. F., M. L. Janmaat, J. M. Reichert, and P. W. H. I. Parren (2019) Bispecific antibodies: a mechanistic review of the pipeline. Nat. Rev. Drug Discov. 18: 585–608.

2. Dickopf, S., G. J. Georges, and U. Brinkmann (2020) Format and geometries matter: structure-based design defines the functionality of bispecific antibodies. Comput. Struct. Biotechnol. J. 18: 1221–1227.

3. Brinkmann, U. and R. E. Kontermann (2017) The making of bispecific antibodies. MAbs 9: 182–212.

4. Spiess, C., Q. Zhai, and P. J. Carter (2015) Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol. Immunol. 67: 95–106.

5. Wang, Q., Y. Chen, J. Park, X. Liu, Y. Hu, T. Wang, K. McFarland, and M. J. Betenbaugh (2019) Design and production of bispecific antibodies. Antibodies (Basel) 8: 43.

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