AN INHERITABLE STROKE DISORDER PRESENTING WITH UNIPOLAR PSYCHOTIC DEPRESSION: CASE REPORT OF A RARE ENTITY
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Published:2023-01-01
Issue:
Volume:
Page:51-53
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ISSN:
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Container-title:INDIAN JOURNAL OF APPLIED RESEARCH
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language:en
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Short-container-title:IJAR
Affiliation:
1. Resident, Department Of Internal Medicine, Bangalore Medical College And Research Institute.
Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an
autosomal dominant rare hereditary angiopathy that causes stroke in young patients. Most frequent clinical presentations
include ischemic strokes, recurrent transient ischaemic attacks and migraine with aura. Psychiatric manifestations are conspicuously rare and
especially if present as the only presenting manifestation. Here is a case of a female patient in her fties who was diagnosed with major depressive
disorder with psychotic features and was on medication for the same for one and a half years with no improvement in symptoms. She was
subsequently admitted due to an increased tendency to self-harm and on day 6 of admission had an episode of seizures, which led us to look for
organic causes. After a battery of tests and ruling out various differentials, she underwent an MRI which revealed T2 hyperintense signal in
bilateral frontal, temporal, parieto-occipetal, and periventricular white matter. Based on MRI ndings, family history of her father passing away
due to a stroke at age 68 and poor response to antidepressants, she was suspected to have CADASIL. She underwent genetic testing which
conrmed the same. The clinical course and distinct facts of the case are divulged below.
Publisher
World Wide Journals
Subject
Safety, Risk, Reliability and Quality,Nuclear Energy and Engineering,General Engineering,General Engineering,Nuclear and High Energy Physics,Nuclear and High Energy Physics,General Energy,Mechanical Engineering,Waste Management and Disposal,Safety, Risk, Reliability and Quality,General Materials Science,Nuclear Energy and Engineering,Nuclear and High Energy Physics,General Engineering,Nuclear Energy and Engineering,Condensed Matter Physics,Nuclear and High Energy Physics
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