Author:
Domenga Valérie,Fardoux Peggy,Lacombe Pierre,Monet Marie,Maciazek Jacqueline,Krebs Luke T.,Klonjkowski Bernard,Berrou Eliane,Mericskay Matthias,Li Zhen,Tournier-Lasserve Elisabeth,Gridley Thomas,Joutel Anne
Abstract
Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC). In adult Notch3–/– mice distal arteries exhibit structural defects and arterial myogenic responses are defective. The postnatal maturation stage of vSMC is deficient in Notch3–/– mice. We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC.
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
438 articles.
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