Targeting Hepatic Glucokinase in Type 2 Diabetes
Author:
Affiliation:
1. From the Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, U.K
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://journals.org/diabetes/diabetes/article-pdf/58/1/18/513343/zdb00109000018.pdf
Reference20 articles.
1. Agius L: Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J 414:1–18,2008
2. Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J: The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes 55:1–12,2006
3. Coghlan M, Leighton B: Glucokinase activators in diabetes management. Expert Opin Investig Drugs 17:145–167,2008
4. Agius L: New hepatic targets for glycaemic control in diabetes. Best Pract Res Clin Endocrinol Metab 21:587–605,2007
5. Basu A, Basu R, Shah P, Vella A, Johnson CM, Nair KS, Jensen MD, Schwenk WF, Rizza RA: Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. Diabetes 49:272–283,2000
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