In Silico Studies on the Antidiabetic activity of Avicularin

Abstract

Type 2 diabetes mellitus (T2DM) is a worldwide public health crisis. The existing treatments have limitations such as undesirable side effects such as hypoglycemia, unusual weight gain and the development of resistance after prolonged use, which necessitates the development of new therapies for paramount glycemic control, especially those of plant origin. Avicularin, a plant flavonoid and a quercetin glycoside, was originally purified from Psidium guajava. It has been reported to elicit a wide range of pharmacological and beneficial properties especially striking antidiabetic activity. In-silico models have been recognized as being of fundamental importance in the area of research and development of drugs due to their applications both in the evaluation of bioactive substances and in relation to their physicochemical and pharmacokinetic properties, giving rise to a new model of drug design with greater value and efficiency. The aim of the present study was to analyze the molecular interactions between Avicularin andprominent target proteins involved in the commencement and development of diabetes and its secondary complications using an in silico approach.