Affiliation:
1. Diabetes Research Institute, University of Düsseldorf Aufm Hennekamp 65, D-4000 Düsseldorf, Federal Republic of Germany
Abstract
Administration of silica to young BB-rats almost completely prevented the development of spontaneous diabetes. Only 1 of 31 silica-treated rats developed hyperglycemia, whereas 9 of 31 in the untreated group did so. Since silica is highly specific in its action against macrophages, our observations indicate an important role of these cells in the pathogenesis of the disease.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
75 articles.
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