TNF-α Antibody Therapy in Combination With the T-Cell–Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat
Author:
Affiliation:
1. Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
2. Centre for Anatomy, Hannover Medical School, Hannover, Germany
3. Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany
Abstract
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://journals.org/diabetes/diabetes/article-pdf/64/8/2880/580882/db141866.pdf
Reference51 articles.
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2. Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity;Knight;Diabetes,2013
3. Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes;Jörns;Diabetologia,2014
4. Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes;Arnush;J Immunol,1998
5. Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat;Jörns;Diabetes,2005
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