Effect of Renal Insufficiency on the Pharmacokinetics of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor

Author:

Bergman Arthur J.1,Cote Josee1,Yi Bingming1,Marbury Thomas2,Swan Suzanne K.3,Smith William4,Gottesdiener Keith1,Wagner John1,Herman Gary A.1

Affiliation:

1. Merck Research Laboratories, West Point, Pennsylvania

2. Orlando Clinical Research Center, Orlando, Florida

3. DaVita Clinical Research, Hennepin County Medical Center, Minneapolis, Minnesota

4. New Orleans Center for Clinical Research, Knoxville, Tennessee

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference6 articles.

1. Kim D, Wang L, Beconi M, Eiermann GJ, Fisher MH, He H, Hickey GJ, Kowalchick JE, Leiting B, Lyons K, Marsilio F, McCann ME, Patel RA, Petrov A, Scapin G, Patel SB, Roy RS, Wu JK, Wyvratt MJ, Zhang BB, Zhu L, Thornberry NA, Weber AE: (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyra-zin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)-butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem 48:141–151, 2005

2. Herman GA, Stevens C, Van Dyck K, Bergman A, Yi B, De Smet M, Snyder K, Hilliard D, Tanen M, Tanaka W, Wang AQ, Chen L, Zeng W, Musson D, Laethem M, Zhou YY, Winchell G, Davies MJ, Ramael S, Gottesdiener KM, Wagner JA: Pharmacokinetics and pharmacodynamics of single doses of sitagliptin, an inhibitor of dipeptidyl peptidase-IV, in healthy subjects. Clin Pharm Therap 78:675–688, 2005

3. Zeng W, Wang AQ, Fisher A: L., Musson DG: Determination of MK-0431 in human plasma using high turbulence liquid chromatography online extraction and tandem mass spectrometry. Rapid Commun Mass Spectrom 20:1169–1175, 2006

4. Rowland M, Tozer T: Appendix I: Additional concepts and derivations. In Clinical Pharmacokinetics: Concepts and Applications. Baltimore, MD, Williams & Wilkins, 1995, p. 469–506

5. Bergman AJ, Stevens C, Zhou YY, Yi B, Laethem M, De Smet M, Snyder K, Hilliard D, Tanaka W, Zeng W, Tanen M, Wang AQ, Chen L, Winchell G, Davies MJ, Ramael S, Wagner JA, Herman GA: Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebo-controlled study in healthy male volunteers. Clin Ther 28:55–72, 2006

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