High-Dose Resveratrol Supplementation in Obese Men

Author:

Poulsen Morten M.1,Vestergaard Poul F.1,Clasen Berthil F.1,Radko Yulia2,Christensen Lars P.2,Stødkilde-Jørgensen Hans3,Møller Niels1,Jessen Niels4,Pedersen Steen B.1,Jørgensen Jens Otto L.1

Affiliation:

1. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

2. Institute of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark

3. Magnetic Resonance Research Centre, Aarhus University Hospital, Aarhus, Denmark

4. Department of Pharmacology, Aarhus University Hospital, Aarhus, Denmark

Abstract

Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data in human subjects are scarce. The objective of this study was to examine the metabolic effects of high-dose resveratrol in obese human subjects. In a randomized, placebo-controlled, double-blinded, and parallel-group design, 24 obese but otherwise healthy men were randomly assigned to 4 weeks of resveratrol or placebo treatment. Extensive metabolic examinations including assessment of glucose turnover and insulin sensitivity (hyperinsulinemic euglycemic clamp) were performed before and after the treatment. Insulin sensitivity, the primary outcome measure, deteriorated insignificantly in both groups. Endogenous glucose production and the turnover and oxidation rates of glucose remained unchanged. Resveratrol supplementation also had no effect on blood pressure; resting energy expenditure; oxidation rates of lipid; ectopic or visceral fat content; or inflammatory and metabolic biomarkers. The lack of effect disagrees with persuasive data obtained from rodent models and raises doubt about the justification of resveratrol as a human nutritional supplement in metabolic disorders.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference53 articles.

1. World Health Organization. 2012. Obesity and overweight. Fact sheet no. 311 [report online]. Available from http://www.who.int/mediacentre/factsheets/fs311/en/index.html. Accessed 12 November 2012

2. Successful weight loss maintenance;Wing;Annu Rev Nutr,2001

3. Resveratrol and health—a comprehensive review of human clinical trials;Smoliga;Mol Nutr Food Res,2011

4. A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine;Stervbo;Food Chem,2007

5. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice;Barger;PLoS One,2008

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