HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study-Reference-Cited by-同舟云学术

HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study

Published:2023-08-14 Issue:10 Volume:46 Page:1839-1847
ISSN:0149-5992
Container-title:Diabetes Care
language:en
Short-container-title:

Author:

Uusitalo Ulla¹^ORCID,Mramba Lazarus K.¹,Aronsson Carin Andrén²,Vehik Kendra¹,Yang Jimin¹,Hummel Sandra³,Lernmark Åke²,Rewers Marian⁴,Hagopian William⁵,McIndoe Richard⁶,Toppari Jorma⁷⁸,Ziegler Anette-G.³,Akolkar Beena⁹,Krischer Jeffrey P.¹,Virtanen Suvi M.¹⁰¹¹¹²¹³,Norris Jill M.¹⁴,

Affiliation:

1. 1Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL

2. 2Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital, Malmö, Sweden

3. 3Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München and Forschergruppe Diabetes e.V., Munich, Germany

4. 4Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO

5. 5Pacific Northwest Diabetes Research Institute, Seattle, WA

6. 6Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA

7. 7Research Center for Integrative Physiology and Pharmacology, Institute of Biomedicine, and Center for Population Health Research, University of Turku, Turku, Finland

8. 8Department of Pediatrics, Turku University Hospital, Turku, Finland

9. 9National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

10. 10Finnish Institute for Health and Welfare, Health and Welfare Promotion Unit, Helsinki, Finland

11. 11Faculty of Social Sciences/Health Sciences Unit, Tampere University, Tampere, Finland

12. 12Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland

13. 13The Science Center of Pirkanmaa Hospital District, Tampere, Finland

14. 14Department of Epidemiology, University of Colorado Denver, Colorado School of Public Health, Aurora, CO

Abstract

OBJECTIVETo study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA).RESEARCH DESIGN AND METHODSThe Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children.RESULTSAny solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4–5.9 months compared with later in the U.S. was associated with an increased risk of IA.CONCLUSIONSTiming of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study.

Funder

NIH/NCATS

University of Colorado

Centers for Disease Control and Prevention

Juvenile Diabetes Research Foundation United States of America

National Institutes of Health

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute of Environmental Health Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Allergy and Infectious Diseases

Publisher

American Diabetes Association