Affiliation:
1. Youjiang Medical University for Nationalities
2. Affiliated Hospital of Youjiang Medical University for Nationalities
Abstract
Abstract
Background
Current understanding of the link between gut microbiota (GM) and frozen shoulder (FS) remains limited. This study employs the R software for a two-sample Mendelian randomization (MR) analysis to investigate their causal relationship.
Method
Our study is based on publicly available genome-wide association studies (GWAS). It utilizes GM data from 18,340 participants as the exposure and FSdata from 451,099 individuals as the outcome. The primary analytical method employed is the inverse-variance weighted (IVW) approach. Complementary analyses include the weighted median, MR-Egger, simple mode, and weighted mode methods. Additionally, heterogeneity is assessed using the Cochran Q test. Pleiotropy is evaluated using the MR-Egger intercept and MR-PRESSO analysis. The robustness of our findings is ensured through leave-one-out analysis.
Results
The IVW analysis reveals that certain GM, including Gammaproteobacteria (OR = 0.83, p = 0.019), Bifidobacteriales (OR = 0.85, p = 0.018), Alcaligenaceae (OR = 0.88, p = 0.047), Bifidobacteriaceae (OR = 0.85, p = 0.018), Lachnospiraceae UCG-004 (OR = 0.87, p = 0.038), Lactobacillus (OR = 0.91, p = 0.042), and Ruminococcaceae UCG-003 (OR = 0.83, p = 0.009), act as protective factors against FS. Conversely, Alphaproteobacteria (OR = 1.19, p = 0.007), Peptococcaceae (OR = 1.15, p = 0.028), and Porphyromonadaceae (OR = 1.24, p = 0.016) are identified as risk factors for FS. The reliability of these findings is bolstered by a series of rigorous tests.。
Conclusion
A potential causal link between FS and specific types of GM has been confirmed in the current study.
Publisher
Research Square Platform LLC
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