Islet Mass and Function in Diabetes and Transplantation

Abstract

The concept of pancreatic β-cell mass is fundamental to the understanding of normal metabolism, the pathogenesis of diabetes, and the transplantation of β-cell tissue. The amount of β-cell tissue present in the pancreas is a major determinant of the quantity of insulin that can be secreted, and its mass will vary according to the size of the individual and the degree of insulin resistance present. Not all insulin-producing cells are the same, and the dimensions of this heterogeneity remain to be defined. Pancreatic β-cell mass is markedly reduced in insulin-dependent diabetes mellitus and moderately reduced in non-insulin-dependent diabetes mellitus. In both forms of diabetes, there are qualitative and quantitative abnormalities of insulin secretion that cannot be explained entirely by changes in β-cell mass. The amount of β-cell tissue needed for successful transplantation has only been partially defined. Segmental (∼50% of the pancreas) transplantation can normalize plasma glucose levels in humans. Difficulty obtaining sufficient amounts of β-cell tissue is expected to remain a barrier to successful islet transplantation for the immediate future. More should be learned about the function and fate of grafted islet cells.